Creators of QAI Reactor Matrix™- Integral Membrane Protein Drug Target Discovery System
SUPRACHEM is a CRO specializing in Integral Membrane Protein (IMP) target de novo drug discovery. We apply our QAI Reactor Matrix™ to design IMP target focused libraries.
An IMP is a type of membrane protein permanently attached to the cell biological membrane. IMPs comprise a significant fraction of the proteins encoded in an organism's genome. Paradoxically, only ~2% of crystal structures deposited in the protein data bank are of membrane proteins, and very few of these are at high resolution (better than 2 angstroms).
IMPs have essential roles in numerous physiological functions, such as molecular recognition, energy transduction and ion regulation. Despite the experimental challenges of studying these proteins, understanding them is crucial because they represent more than 60% of therapeutic drug targets. These intractable drug targets are SUPRACEM'S specialty.
“During our [year and a half] relationship, they [Suprachem] have developed new algorithms and tools that allow for direct visualization of the sub-atomic interactions that makes their tools so unique. The use of these visualizations have allowed us to have meaningful conversations about the results and to see the important features and relationships between the molecules. These specific visualizations are unique [to Suprachem], and provide a view of the intermolecular interactions that is not available with other tools.” -- DUPONT
"Intractable Integral Membrane Protein Drug Target
Lead Candidates Are Designed Using QAI Reactor Matrix™"
Creators of the QAI Reactor Matrix™ Integral Membrane Protein Drug Target Discovery System
VIDEOS FROM SUPRACHEM
See what the experts in the field have to say about our approach.
SUPRACHEM Reference: Dr. Stuart Kauffman
MacArthur Fellow, FRSC
"RE: Lars Wood & SUPRACHEM
Stuart Kauffman, MacArthur Fellow, FRSC
Emeritus University of Pennsylvania
Distinguished Finnish Professor
Tampere University of Technology
Distinguished Visiting Professor
University of Vermont
Aug 6, 2011
I am pleased to write on behalf of my old friend, Lars Wood. I have known Lars since 1993, when he was a stunning young scientist at GTE, having won awards for innovative research. I have followed Lars’s work at a distance over the years. At present, I am modestly familiar with a number of aspects of quantum mechanics as a biologist, and have recently filed a US Utility Patent in this area, owned by the two universities where I am a faculty member. This background allows me a modest capacity to evaluate Lars’s iHEXIS article about his super-Turing system and its use in quantum chemistry beyond the Born - Oppenheimer approximation to deal with the many body problem in quantum chemistry. As long ago as Poincare’ and the three body gravitational problem, Poincare’ showed that due to what is now known as sensitivity to initial conditions, the behavior of the classical physics system was deterministic, but not predictable due to the fact that any measurement requires finite length and time interval. If I understand Lars’s work, the use of an approximation on a manifold where either phase or amplitude varies slowly, allowing one to surpass the standard Born - Oppenheimer approximation of nuclei fixed in space, is a very important step forward. I cannot judge whether Lars’s approach is, in fact, successful, although he does present confirming evidence that must be taken seriously. Thus, I feel right making these points about Lars Wood. He is brilliant, radically creative, and deeply worth serious consideration by those with the real expertise to evaluate his work. Suprachem’s approach seems to be a major step forward in quantum chemistry and other applications, and warrants serious attention.
SUPRACHEM Reference: Sidney Pestka, M.D.
Founder, Chairman and CSO, Pestka Biomedical Laboratories, Inc.
Author of 400+ papers and holder of 270 patents
2001 National Medal of Technology presented by President George W. Bush
2004 Warren Alpert Foundation Scientific Prize from Harvard Medical School
2006 Lemelson-MIT Lifetime Achievement Award
2009 Molecular Biology Medal from the National Institutes of Health for his role in deciphering the genetic code and the mechanism of protein synthesis
2010 Edward J. II Outstanding Medical Research Scientist Award for Basic Biomedical Research
Aug 19, 2011
I have known Lars since 2005 when he and his wife and partner Lisa visited me in my lab at PBL Therapeutics. I have since remained genuinely interested in Lars’s technology and research. In 2007 we collaborated in the co-discovery of a novel large molecule structure determination method based upon Lars’s calculation of an efficient infrared spectrum quantum mechanical vibration linear calculation and my observation that this might be coupled to my experimental work in infrared and raman spectroscopy to rapidly determine the structure of large molecules and possibly membrane based protein drug targets with femtometer resolution. This new Optical Structure Determination (OSD) method could revolutionize structure determination if it is successful. In 2006 Lars participated in one of our NIH funded initiatives whereby he applied the novel OSD methodology and Suprachem technology in a first step to analyze the structure of the twenty-one amino acids, which are the building blocks of proteins. We also collaborated in laboratory experiments to assess the predictive capabilities of Lars’s femotjoule quantum chemistry technology to understand the in vitro qualities of the C60 molecule for use as a possible human Erythropoietin drug scaffold. I will continue to enjoy working with Lars and following his resulting accomplishments.
Sidney Pestka, M.D."
SUPRACHEM Reference: DUPONT
During our [year and a half] relationship, they [Suprachem] have developed new algorithms and tools that allow for direct visualization of the sub-atomic interactions that makes their tools so unique. The use of these visualizations have allowed us to have meaningful conversations about the results and to see the important features and relationships between the molecules. These specific visualizations are unique [to Suprachem], and provide a view of the intermolecular interactions that is not available with other tools.
In 1995, Lars and Lisa Wood began what is now a two decade-long journey together to develop science and technology to address critical intractable challenges in biotechnology, artificial intelligence and beyond. Lars' decade long career as a cold war scientist had come to a close, and Lisa, an independent corporate custom publisher with a top big business magazine, had decided to fund the venture and spend available time working with Lars.
Lars' career centered on solving computationally intractable challenges through the development of novel asymmetric technologies. Since the early 1990s he has developed quantum chemistry algorithms that avoid the intractable many body problem yet retain the accuracy of fully correlated calculations. This algorithmic research lead to development of what Wood refers to as Energy Mechanics, enabling quantum chemistry precision without exponential computational limitations. Energy Mechanics, which fundamentally re-defines quantum theory in the context of force carrier, as opposed to matter constituent, interactions provides for high precision quantum chemistry predictions. This was first applied and refined to the design of novel small molecules for pharmaceutical and agrochemical purposes.
© 2016 copyright by SUPRACHEM All rights reserved.